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Evan Hersh Selected Research

4- imino- 1,3- diazabicyclo(3.1.0)hexan- 2- one

1/2018A Phase 2 Randomized, Double-Blind, Multicenter Trial of Imexon Plus Gemcitabine Versus Gemcitabine Plus Placebo in Patients With Metastatic Chemotherapy-naïve Pancreatic Adenocarcinoma.
10/2010A phase I trial of imexon, a pro-oxidant, in combination with docetaxel for the treatment of patients with advanced breast, non-small cell lung and prostate cancer.
8/2010A phase 1-2 study of imexon plus dacarbazine in patients with unresectable metastatic melanoma.
5/2007Phase I trial of imexon in patients with advanced malignancy.
11/2006Preclinical antitumor activity, pharmacokinetics and pharmacodynamics of imexon in mice.

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Evan Hersh Research Topics

Disease

7Melanoma (Melanoma, Malignant)
08/2010 - 01/2002
6Neoplasms (Cancer)
04/2010 - 11/2005
1Adenocarcinoma
01/2018
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
10/2010
1Prostatic Neoplasms (Prostate Cancer)
10/2010
1Disease Progression
04/2010
1Circulating Neoplastic Cells
04/2010
1Alopecia (Baldness)
11/2005
1Edema (Dropsy)
11/2005
1Fatigue
11/2005
1Nausea
11/2005
1Neutropenia
11/2005
1Ovarian Neoplasms (Ovarian Cancer)
11/2005
1Peripheral Nervous System Diseases (PNS Diseases)
11/2005
1Ileus
11/2005

Drug/Important Bio-Agent (IBA)

54- imino- 1,3- diazabicyclo(3.1.0)hexan- 2- oneIBA
01/2018 - 11/2006
2Reactive Oxygen Species (Oxygen Radicals)IBA
10/2010 - 11/2006
2Dacarbazine (DIC)FDA LinkGeneric
08/2010 - 05/2008
2VaccinesIBA
02/2008 - 10/2007
1GemcitabineFDA Link
01/2018
1Docetaxel (Taxotere)FDA Link
10/2010
1Biomarkers (Surrogate Marker)IBA
04/2010
1RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA
04/2010
1IpilimumabIBA
12/2008
1Sorafenib (BAY 43-9006)FDA Link
05/2008
1A-Form DNA (A-DNA)IBA
02/2008
1Monophenol Monooxygenase (Tyrosinase)IBA
02/2008
1Differentiation AntigensIBA
02/2008
1T-Lymphocyte Epitopes (Epitopes, T Lymphocyte)IBA
02/2008
1DNA (Deoxyribonucleic Acid)IBA
02/2008
1AntigensIBA
02/2008
1Amino AcidsFDA Link
02/2008
1MART-1 AntigenIBA
02/2008
1Immunologic Adjuvants (Immunologic Adjuvant)IBA
10/2007
1CytokinesIBA
10/2007
1Sulfhydryl Compounds (Thiols)IBA
11/2006
1Paclitaxel (Taxol)FDA LinkGeneric
11/2005
1tasidotinIBA
11/2005
1Albumin-Bound PaclitaxelFDA Link
11/2005
1AcidsIBA
11/2005
1Alanine Transaminase (SGPT)IBA
11/2005
1AlbuminsIBA
11/2005
1Transaminases (Aminotransferases)IBA
11/2005
1Aspartic Acid (Aspartate)FDA Link
11/2005
1Carrier Proteins (Binding Protein)IBA
11/2005
1Castor Oil (Oil, Castor)IBA
11/2005
1Cysteine (L-Cysteine)FDA Link
11/2005
1Proteins (Proteins, Gene)FDA Link
11/2005
1SolventsIBA
11/2005
1Albumin ReceptorsIBA
11/2005
1Histamine (Histamine Dihydrochloride)FDA Link
01/2002
1Interleukin-2 (IL2)IBA
01/2002

Therapy/Procedure

3Drug Therapy (Chemotherapy)
01/2018 - 05/2008
1Therapeutics
01/2018
1Biological Therapy
04/2010
1Intravenous Infusions
11/2005
1Premedication
11/2005